Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net	Kernel	Elements	Min	Max	Average	Standard_Deviation
biological_process	ct	70	0.0	0.723	0.079	0.159
biological_process	el	70	0.011	0.966	0.618	0.246
biological_process	ka	70	0.0	0.698	0.075	0.158
biological_process	rf	70	0.0	0.723	0.079	0.159
cellular_component	ct	71	0.0	0.874	0.125	0.196
cellular_component	el	71	0.007	0.994	0.578	0.27
cellular_component	ka	71	0.0	0.886	0.128	0.198
cellular_component	rf	71	0.0	0.87	0.125	0.195
genetic_interaction_weighted	ct	73	0.0	0.996	0.304	0.297
genetic_interaction_weighted	el	73	0.007	0.996	0.53	0.297
genetic_interaction_weighted	ka	73	0.0	0.994	0.302	0.289
genetic_interaction_weighted	node2vec	73	0.0	0.981	0.458	0.336
genetic_interaction_weighted	rf	73	0.0	0.996	0.304	0.297
molecular_function	ct	71	0.0	0.994	0.148	0.279
molecular_function	el	71	0.002	0.959	0.527	0.267
molecular_function	ka	71	0.0	0.975	0.151	0.277
molecular_function	rf	71	0.0	0.994	0.148	0.279
phenotype	ct	26	0.0	0.864	0.203	0.272
phenotype	el	26	0.03	0.853	0.497	0.195
phenotype	ka	26	0.0	0.968	0.22	0.299
phenotype	rf	26	0.0	0.867	0.203	0.272

Table 2. Backup position values for every kernel after integration

Integration	Kernel	Elements	Min	Max	Average	Standard_Deviation
integration_mean_by_presence	ct	73	0.0	0.958	0.132	0.224
integration_mean_by_presence	el	73	0.025	0.945	0.408	0.255
integration_mean_by_presence	ka	73	0.0	0.623	0.054	0.122
integration_mean_by_presence	node2vec	73	0.0	0.981	0.458	0.336
integration_mean_by_presence	rf	73	0.0	0.72	0.141	0.141
mean	ct	73	0.0	0.964	0.138	0.233
mean	el	73	0.006	0.945	0.38	0.25
mean	ka	73	0.0	0.503	0.044	0.102
mean	node2vec	73	0.0	0.981	0.458	0.336
mean	rf	73	0.0	0.689	0.114	0.139

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels